aerosols containing beclomethasone nanoparticle dispersions

US4810488A - Physically modified beclomethasone ...

A method for preparing a stable aerosol formulation of beclomethasone dipropionate in which the steroid is contacted with an alcohol containing 1 to 5 carbon atoms to form a crystalline solvate therewith, the crystalline material so formed being reduced to a particle size below 10 microns and thereafter dispersed in a composition comprising chlorofluorocarbon propellents.

Alternatives to conventional suspensions for pulmonary ...

Nov 01, 2011· The drug‐containing aerosols to treat the lung diseases have been used for millennia. ... The first nanosuspension‐based preparation introduced for nebulisation purposes was a physically stable NanoCrystal TM dispersion of beclomethasone dipropionate (BDP) in an aqueous medium with the mean particle size of 267 nm. The nanodispersion was ...

Aerosolisation of beclomethasone dipropionate using spray ...

The performance of dry powder aerosols for pulmonary delivery is known to depend on fluidization and dispersion which reflects particle interactions in static powder beds.

Electrostatics of pharmaceutical inhalation aerosols ...

Jan 08, 2010· Aerosol charge profiles were dependent on the drug, excipients (e.g. lactose carrier), and inhaler. 18-20, 22 Respirable particles were estimated to carry charge levels high enough to affect deposition. 18, 22 Charge separation occurred from the dispersion of aggregates. 18, 19 The extent and trends of charging were affected by storage and ...

Short-Term Rat Inhalation Study With The Author(s) 2012 ...

Short-Term Rat Inhalation Study With Aerosols of Acrylic Ester-Based Polymer Dispersions Containing a Fraction of Nanoparticles Lan Ma-Hock1, Robert Landsiedel1, Karin Wiench2, Dominik Geiger2, Volker Strauss1, Sibylle Gro¨ters1, Bennard van Ravenzwaay1, Matthias Gerst3, Wendel Wohlleben3 and Gertrud Scherer4 Abstract

US6264922B1 - Nebulized aerosols containing nanoparticle ...

There is disclosed an aerosol comprising droplets of an aqueous dispersion of nanoparticles, said nanoparticles comprising insoluble therapeutic or diagnostic agent particles having a surface modifier on the surface thereof. There is also disclosed a method for making the aerosol and methods for treatment and diagnosis using the aerosol.

Ray W. Wood Inventions, Patents and Patent Applications ...

Jan 11, 2012· Nanoparticulate beclomethasone dipropionate compositions. Publication number: 20040057905 Abstract: There is disclosed an aerosol comprising droplets of an aqueous dispersion of nanoparticles, said nanoparticles comprising insoluble therapeutic or diagnostic agent particles having a surface modifier on the surface thereof. There is also ...

Aerosols containing beclomethasone nanoparticle dispersions

Feb 23, 1996· Aerosols containing beclomethasone nanoparticle dispersions (PAT - EP1354583) Wiedmann ... There is disclosed an aerosol comprising droplets of an aqueous dispersion of nanoparticles, said nanoparticles comprising insoluble beclomethazone particles having a surface modifier on the surface thereof. There is also disclosed a method for making the ...

Reduction of flake-like aggregation in nanoparticulate ...

Apr 15, 2016· Aerosols containing beclomethazone nanoparticle dispersions: 1998-05-05: Wiedmann et al. 5741522: Ultrasmall, non-aggregated porous particles of uniform size for entrapping gas bubbles within and methods: 1998-04-21: Violante et al. 5718919: Nanoparticles containing the R(-)enantiomer of ibuprofen: 1998-02-17: Ruddy et al. 5718388

Pharmaceutics | Free Full-Text | Inhalable PEGylated ...

Nanomedicine is making groundbreaking achievements in drug delivery. The versatility of nanoparticles has given rise to its use in respiratory delivery that includes inhalation aerosol delivery by the nasal route and the pulmonary route. Due to the unique features of the respiratory route, research in exploring the respiratory route for delivery of poorly absorbed and systemically unstable ...

Preparation of polymeric nanoparticles containing ...

The polymeric drug-containing nanoparticles prepared consist of a poorly water soluble corticosteroid, beclomethasone dipropionate, and polymeric materials Eudragit E 100 or Eudragit L 100.

Preparation of nanoparticles consisting of methacrylic ...

Figure 2.Schematic representation of a model depicting the dissolution process [113].. Figure 3.Diagrammatic representation of a solid carboxylic acid, HA, dissolving into a reactive medium containing h ydroxide ion and buffer components B and BH + with a Nernst diffusion layer existing between the solid and the bulk solution. Sink conditions exist in the bulk solution, and the products, BH ...

Nanomaterials | Free Full-Text | Loading of Beclomethasone ...

Beclomethasone dipropionate in dispersion or loaded in liposomes, mucin-liposomes or hyalurosomes was not able to counteract the ROS production caused by the cigarette smoke extract on epithelial bronchial cells. Indeed, the values were still ~ (p > 0.05 …

Aerosols containing beclomethazone nanoparticle dispersions

An aerosol of an aqueous dispersion of nanoparticles, wherein the nanoparticles comprise 0.1 to 60% (w/w) of insoluble beclomethasone particles having (1) an average particle size of less than about 400 nm, and (2) 0.1 to 90% (w/w) of a surface modifier adsorbed on the surface thereof.

Colloids and Aerosols Flashcards | Quizlet

a pressurized dosage form containing one or more active ingredients which upon actuation emit a fine dispersion of liquid and/or solid materials in a gaseous medium. aerosols Falls into the coarse dispersions category

AEROSOL AND INJECTABLE FORMULATIONS OF …

Aug 19, 2009· Such aerosols comprise a higher number of nanoparticles per unit dose, resulting in each aerosolized droplet containing active benzodiazepine, such as lorazepam. Thus, with administration of the same dosages of nanoparticulate and micronized benzodiazepine, such as lorazepam, more lung or nasal cavity surface area is covered by the aerosol ...

US Patent for Nanoparticulate dispersions comprising a ...

Feb 15, 2002· Disclosed are solid dose nanoparticulate compositions comprising a poorly soluble active agent, at least one polymeric surface stabilizer, and dioctyl sodium sulfosuccinate (DOSS). The solid dose compositions exhibit superior redispersibility of the nanoparticulate composition upon administration to a mammal, such as a human or animal. The invention also describes methods of making and using ...

Preparation of Nanoparticle Dispersions from Powdered ...

preparation of nanoparticle dispersions in liquid media by the application of ultrasonic energy (a process referred to here as sonication). It applies specifically to engineered nanoscale materials (ENM) obtained in dry powder form, but can be extended to the treatment of previously suspended ENMs (e.g., for purposes of re-dispersion).

(PDF) Aerosol flow reactor method for synthesis of drug ...

An aerosol flow reactor method, a one-step continuous process to produce nanometer-sized drug particles with unimodal size distribution, was developed.

Characterization of size, surface charge, and ...

Jun 25, 2008· Chemicals. Seven different nanoparticles were used in this study, as listed in Table 1.Anatase TiO 2 (H) and (S) with primary particle sizes of 15 nm and 26 nm, respectively, and specific surface areas of 102.1 m 2 /g and 61.5 m 2 /g, respectively, were synthesized via a flame aerosol reactor (Jiang et al. 2007, 2008).The precursor used to synthesize TiO 2 particles was titanium tetra ...

DE69637288T2 - Beclomethasone nanoparticle dispersions ...

Beclomethasone nanoparticle dispersions containing aerosols Download PDF Info ... Authority DE Germany Prior art keywords aerosol beclomethasone modifier particles rhinitis Prior art date 1995-02-24 Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no ...

Aerosols - SlideShare

Dec 04, 2014· Definition and Types of Aerosols • An aerosol is a two-phase system defined as a dispersion or suspension of solid particles or liquid droplets in a gaseous medium (air, oxygen, heliox) 5. Middleton 8th edition 6.

EP0810853A1 - Aerosols containing nanoparticle dispersions ...

There is disclosed an aerosol comprising droplets of an aqueous dispersion of nanoparticles, said nanoparticles comprising insoluble therapeutic or diagnostic agent particles having a surface modifier on the surface thereof. There is also disclosed a method for making the aerosol and methods for treatment and diagnosis using the aerosol.

Short-term rat inhalation study with aerosols of acrylic ...

Short-term rat inhalation study with aerosols of acrylic ester-based polymer dispersions containing a fraction of nanoparticles Int J Toxicol . Jan-Feb 2012;31(1):46-57. doi: 10.1177/1091581811424778.

Optimizing drug delivery in COPD: The role of inhaler ...

Mar 01, 2017· Beclomethasone diproprionate, budesonide, formoterol fumarate, salbutamol. ... The new pMDIs produce aerosols containing extra-fine particles with equivalent efficacy to other preparations, but with a reduced dosage. ... and, when added to the pMDIs, they reduce the velocity of the emitted aerosol, decrease aerosol dispersion when inhalation is ...

Understanding nanoparticle aggregation

nanoparticles are designed empirically and important product properties such as polydispersity are typically controlled by varying the process conditions [8]. In colloidal (liquid phase) or aerosol (gas phase) reactors for the synthesis of nanoparticles [9], turbulent mixing brings the chemical precursors

Inhaled nanoparticles—A current review - ScienceDirect

May 22, 2008· One is designed for pulmonary delivery (ITZ-pulmonary). Eight milliliters of the aqueous colloidal dispersion of the ITZ-pulmonary nanoparticles (containing 200 mg of ITZ equivalent) was aerosolized by a micropump nebulizer. The aerosols were administered to mice via inhalation exposure for 20 min at a dose of 30 mg/kg

Nanosized aerosols from consumer sprays: experimental ...

Feb 12, 2011· Consumer spray products are already on the market in the cosmetics and sector, which suggest by their label that they contain engineered nanoparticles (ENP). Sprays are considered critical for human health, because the lungs represent a major route for the uptake of ENP into the human body. To contribute to the exposure assessment of ENP in consumer spray products, …